Kenneth S. Zaret, Ph.D.

Kenneth S. Zaret, Ph.D.

Joseph Leidy Professor; Director of the Institute for Regenerative Medicine

Contact Information

The Perelman School of Medicine at the University of Pennsylvania
Department of Cell and Developmental Biology
9-131 Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104-6059
Office: 215-573-5813
Lab: 215-573-5844

Research Interest

Ken’s laboratory discovered “pioneer factors” that bind to silent chromatin, endow the competence for cell differentiation, and promote cellular reprogramming. Recently, his lab found broad chromatin domains that can resist pioneer factor binding and serve as impediments to cellular reprogramming; these domains appear to help commit cells to particular fates. Finally, his lab has unveiled how inductive signaling in the embryo leads to chromatin modifications that affect cell fate choices, thereby identifying specific enzymatic targets for small molecules to modulate cell fate control.

Lab Members

GregoryDonahueComputational Biologist/Senior Data
Ann O'BrienJenkinsResearch Specialist, Animal
NaomiTakenakaResearch Specialist, Lab